376 CARDIAC CONTRACTILITY MODULATION: A NEW THERAPY FOR HEART FAILURE

Abstract Introduction Cardiac Contractility Modulation is a therapy for chronic Heart Failure patients with EF 25-45% in sinus rhythm QRS < 130 ms clinically symptomatic (NYHA Class > II) despite optimised medical therapy. It made possible by the implantation of OPTIMIZER SMART® device. The CCM works delivering non-excitatory high-energy bipolar signal, synchronised local electrical activity (or cooperating another pre-existing CIED), absolute ventricular refractory period, means two actively fixating leads, positioned interventricular septum and spaced at least 1-2 cm apart. Purpose Assessment feedback process dilated cardiomyopathy. Educational update health professionals. Patient education. Method A Pubmed search correlated clinical data field experience was performed. Results Patients severe Dilated Cardiomyopathy already on mechanism action demonstrated remodelling left ventricle so-called 'metabolic' In therapy, stimulation delivered to heart muscle during period. this phase, signals activate mobilisation calcium ions cardiomyocytes. applied period cause an increase cytosolic systole, resulting improved cardiac contraction without oxygen consumption. Conclusions has shown improve contractility performance improving quality life undergoing treatment reducing symptoms fatigue dyspnoea; it reduced number hospitalisations moderate failure. Healthcare professionals recognise typical ECG patient implanted device shows 'spike' cycle: 'R wave' complex being alarmed. been trained be autonomous charging. recharged externally weekly rechargeable battery through mini induction charger, itself.